Multiple Choice
Which name is given to hemoglobin that is carrying oxygen atoms?
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8. Protein Function
Hemoglobin Cooperativity
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Which molecules are typically bound to hemoglobin when it is in the R (relaxed) state?
A
Carbon dioxide (CO\(_2\))
B
Protons (H\(^+\))
C
Oxygen (O\(_2\))
D
2,3-Bisphosphoglycerate (2,3-BPG)
Verified step by step guidance1
Understand the structural states of hemoglobin: Hemoglobin exists in two main conformational states, the T (tense) state and the R (relaxed) state. The T state has a lower affinity for oxygen, while the R state has a higher affinity for oxygen.
Recall the role of oxygen (O\(_2\)) in hemoglobin binding: Hemoglobin transitions to the R state when oxygen binds to its heme groups. This binding increases hemoglobin's affinity for additional oxygen molecules due to cooperative binding.
Consider the molecules listed in the problem: Carbon dioxide (CO\(_2\)), protons (H\(^+\)), and 2,3-Bisphosphoglycerate (2,3-BPG) are typically associated with the T state of hemoglobin, as they stabilize the low-affinity conformation.
Focus on the R state: The R state is stabilized by the binding of oxygen (O\(_2\)), which is the molecule hemoglobin has the highest affinity for in this state.
Conclude the reasoning: Based on the structural and functional properties of hemoglobin, oxygen (O\(_2\)) is the molecule typically bound to hemoglobin in the R (relaxed) state.
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