Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

8. Protein Function

Hemoglobin Cooperativity

Biochemistry

8. Protein Function

Hemoglobin Cooperativity

Previous problemNext problem

Struggling with Biochemistry?

Join thousands of students who trust us to help them ace their exams!Watch the first video

Multiple Choice

Which molecules are typically bound to hemoglobin when it is in the R (relaxed) state?

Carbon dioxide (CO$_2$)

Protons (H$^+$)

Oxygen (O$_2$)

2,3-Bisphosphoglycerate (2,3-BPG)

Previous problemNext problem

Verified step by step guidance

Understand the structural states of hemoglobin: Hemoglobin exists in two main conformational states, the T (tense) state and the R (relaxed) state. The T state has a lower affinity for oxygen, while the R state has a higher affinity for oxygen.

Recall the role of oxygen (O$_2$) in hemoglobin binding: Hemoglobin transitions to the R state when oxygen binds to its heme groups. This binding increases hemoglobin's affinity for additional oxygen molecules due to cooperative binding.

Consider the molecules listed in the problem: Carbon dioxide (CO$_2$), protons (H$^+$), and 2,3-Bisphosphoglycerate (2,3-BPG) are typically associated with the T state of hemoglobin, as they stabilize the low-affinity conformation.

Focus on the R state: The R state is stabilized by the binding of oxygen (O$_2$), which is the molecule hemoglobin has the highest affinity for in this state.

Conclude the reasoning: Based on the structural and functional properties of hemoglobin, oxygen (O$_2$) is the molecule typically bound to hemoglobin in the R (relaxed) state.