Multiple Choice
Which of the following types of enzyme inhibitors primarily target protein conformation?
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7. Enzyme Inhibition and Regulation
Enzyme Inhibition
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Which type of enzyme inhibition occurs when a substrate is unable to bind to an enzyme's active site because an inhibitor occupies the site?
A
Uncompetitive inhibition
B
Allosteric activation
C
Competitive inhibition
D
Noncompetitive inhibition
Verified step by step guidance1
Understand the concept of enzyme inhibition: Enzyme inhibitors are molecules that reduce or prevent the activity of enzymes by interfering with substrate binding or the catalytic process.
Review the types of enzyme inhibition: Competitive inhibition occurs when an inhibitor competes directly with the substrate for binding to the enzyme's active site. Noncompetitive inhibition involves the inhibitor binding to a site other than the active site, altering enzyme function. Uncompetitive inhibition occurs when the inhibitor binds only to the enzyme-substrate complex. Allosteric activation refers to a molecule binding to a site other than the active site to enhance enzyme activity, not inhibit it.
Focus on the mechanism of competitive inhibition: In competitive inhibition, the inhibitor mimics the substrate and occupies the active site, preventing the substrate from binding. This type of inhibition can be overcome by increasing the substrate concentration.
Analyze the problem statement: The question specifies that the substrate is unable to bind to the enzyme's active site because an inhibitor occupies the site. This description matches the mechanism of competitive inhibition.
Conclude the reasoning: Based on the explanation above, the correct type of enzyme inhibition described in the problem is competitive inhibition.
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