Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

4. Protein Structure

Peptide Bond

Biochemistry

4. Protein Structure

Peptide Bond

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Multiple Choice

Which enzyme in the ribosome catalyzes the formation of the peptide bond during protein synthesis?

Peptidyl transferase

Aminoacyl-tRNA synthetase

DNA ligase

RNA polymerase

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Verified step by step guidance

Understand the context of the problem: The question is asking about the enzyme responsible for catalyzing peptide bond formation during protein synthesis, which occurs in the ribosome.

Recall the process of protein synthesis: During translation, the ribosome facilitates the joining of amino acids carried by tRNA molecules to form a growing polypeptide chain. This process involves the formation of peptide bonds between amino acids.

Identify the enzyme involved: The ribosome itself has enzymatic activity, specifically in the large subunit, where the catalytic function is carried out by an RNA molecule rather than a protein. This RNA molecule is known as ribosomal RNA (rRNA), and the enzymatic activity is referred to as peptidyl transferase.

Eliminate incorrect options: Aminoacyl-tRNA synthetase is involved in charging tRNA with amino acids, DNA ligase is involved in DNA repair and replication, and RNA polymerase is responsible for synthesizing RNA from a DNA template. None of these are involved in peptide bond formation during translation.

Conclude that the correct answer is peptidyl transferase, which is the enzymatic activity of the ribosome responsible for catalyzing peptide bond formation during protein synthesis.