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Multiple Choice
In a polypeptide, where are the peptide bonds located?
A
Between the N-terminus and the C-terminus of the entire polypeptide
B
Between the side chains (R groups) of adjacent amino acids
C
Between the phosphate groups and sugars
D
Between the carboxyl group of one amino acid and the amino group of the next amino acid
Verified step by step guidance
1
Understand the structure of a polypeptide: A polypeptide is a chain of amino acids linked together by peptide bonds. Each amino acid has a central carbon atom (α-carbon) bonded to an amino group (-NH2), a carboxyl group (-COOH), a hydrogen atom, and a unique side chain (R group).
Identify the functional groups involved in peptide bond formation: Peptide bonds are formed between the carboxyl group (-COOH) of one amino acid and the amino group (-NH2) of the next amino acid. This reaction is a condensation reaction, meaning a molecule of water (H2O) is released during bond formation.
Clarify the location of peptide bonds: Peptide bonds are located specifically between the carboxyl group of one amino acid and the amino group of the adjacent amino acid in the polypeptide chain. They do not form between the side chains (R groups) or between the N-terminus and C-terminus of the entire polypeptide.
Explain why the other options are incorrect: Peptide bonds do not form between the side chains (R groups) of amino acids, as these groups are not involved in the primary structure of the polypeptide. Similarly, peptide bonds are not related to phosphate groups and sugars, which are components of nucleotides in DNA and RNA, not polypeptides.
Summarize the correct answer: The peptide bonds in a polypeptide are located between the carboxyl group of one amino acid and the amino group of the next amino acid, forming the backbone of the polypeptide chain.