Multiple Choice
What is likely to happen if a frameshift mutation occurs in a gene?
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15. Gene Expression
Mutations
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Which type of DNA mutation results in a change in the reading frame of an mRNA?
A
Missense mutation
B
Silent mutation
C
Frameshift mutation
D
Point mutation
Verified step by step guidance1
Understand the concept of a reading frame: In genetics, the reading frame refers to the way nucleotides in mRNA are grouped into codons, each consisting of three nucleotides. These codons are read sequentially during translation to synthesize proteins.
Identify the types of mutations: A mutation is a change in the DNA sequence. Common types include missense mutations, silent mutations, frameshift mutations, and point mutations.
Define a frameshift mutation: A frameshift mutation occurs when nucleotides are inserted or deleted from the DNA sequence, altering the reading frame. This change affects all downstream codons, potentially leading to a completely different protein sequence.
Contrast with other mutations: Missense mutations result in a single amino acid change, silent mutations do not affect the protein sequence, and point mutations involve a single nucleotide change without necessarily altering the reading frame.
Recognize the impact of frameshift mutations: Since frameshift mutations change the reading frame, they can lead to significant changes in the protein structure and function, often resulting in nonfunctional proteins.
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