Multiple Choice
What is the primary role of exonucleases during DNA replication?
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17. Mutation, Repair, and Recombination
DNA Repair
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What is the role of DNA ligase during DNA replication?
A
It joins Okazaki fragments by forming phosphodiester bonds between adjacent nucleotides.
B
It removes RNA primers from the lagging strand.
C
It synthesizes new DNA strands by adding nucleotides to a template.
D
It unwinds the DNA double helix to allow replication to occur.
Verified step by step guidance1
Understand that DNA replication involves synthesizing new strands complementary to the original DNA strands, and this process occurs differently on the leading and lagging strands.
Recognize that the lagging strand is synthesized discontinuously in short segments called Okazaki fragments, which need to be joined together to form a continuous strand.
Recall that DNA ligase is the enzyme responsible for joining these Okazaki fragments by catalyzing the formation of phosphodiester bonds between adjacent nucleotides.
Differentiate the role of DNA ligase from other enzymes: DNA polymerase synthesizes new DNA strands, helicase unwinds the DNA helix, and enzymes like RNase H remove RNA primers.
Conclude that the specific function of DNA ligase during DNA replication is to seal the gaps between Okazaki fragments, ensuring the integrity and continuity of the newly synthesized DNA strand.
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