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Multiple Choice
During the catabolism of glucose, which chemical compound enters the mitochondria to undergo pyruvate oxidation?
A
Lactate
B
Pyruvate
C
Glucose
D
Acetyl-CoA
Verified step by step guidance
1
Understand the process of glucose catabolism: Glucose is broken down during glycolysis in the cytoplasm to produce two molecules of pyruvate, along with ATP and NADH.
Recognize the role of pyruvate: Pyruvate is the end product of glycolysis and serves as the key compound that enters the mitochondria for further processing.
Explain pyruvate oxidation: Once inside the mitochondria, pyruvate undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, NADH, and CO2.
Clarify why lactate and glucose are not correct: Lactate is produced under anaerobic conditions and does not directly enter the mitochondria for pyruvate oxidation. Glucose is the starting molecule of glycolysis and does not directly participate in pyruvate oxidation.
Highlight the correct answer: Pyruvate is the chemical compound that enters the mitochondria to undergo pyruvate oxidation, leading to the production of acetyl-CoA for the citric acid cycle.