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Multiple Choice
Which of the following correctly indicates the cellular location where pyruvate oxidation occurs?
A
On the inner mitochondrial membrane
B
In the cytoplasm
C
In the mitochondrial matrix
D
In the endoplasmic reticulum
Verified step by step guidance
1
Understand the process of pyruvate oxidation: Pyruvate oxidation is a key step in cellular respiration where pyruvate is converted into acetyl-CoA, releasing carbon dioxide and generating NADH.
Recall the cellular location of pyruvate oxidation: Pyruvate oxidation occurs in eukaryotic cells within the mitochondria, specifically in the mitochondrial matrix.
Eliminate incorrect options: The inner mitochondrial membrane is involved in the electron transport chain, not pyruvate oxidation. The cytoplasm is where glycolysis occurs, and the endoplasmic reticulum is involved in protein and lipid synthesis, not pyruvate oxidation.
Confirm the correct answer: The mitochondrial matrix is the site where pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl-CoA.
Summarize the reasoning: Based on the biochemical pathway and cellular compartmentalization, pyruvate oxidation occurs in the mitochondrial matrix, making it the correct answer.