Table of contents

1. Introduction to Biology2h 42m
2. Chemistry3h 37m
3. Water1h 26m
4. Biomolecules2h 23m
5. Cell Components2h 26m
6. The Membrane2h 31m
7. Energy and Metabolism2h 0m
8. Respiration2h 40m
9. Photosynthesis2h 49m
10. Cell Signaling59m
11. Cell Division2h 47m
12. Meiosis2h 0m
13. Mendelian Genetics4h 44m
14. DNA Synthesis2h 27m
15. Gene Expression3h 6m
16. Regulation of Expression3h 31m
17. Viruses37m
- Viruses
  37m
18. Biotechnology2h 58m
19. Genomics17m
- Genomes
  17m
20. Development1h 5m
21. Evolution3h 1m
22. Evolution of Populations3h 53m
23. Speciation1h 37m
24. History of Life on Earth2h 6m
25. Phylogeny2h 31m
26. Prokaryotes4h 59m
27. Protists1h 12m
28. Plants1h 22m
29. Fungi36m
- Fungi
  19m
- Fungi Reproduction
  17m
30. Overview of Animals34m
- Overview of Animals
  34m
31. Invertebrates1h 2m
32. Vertebrates50m
33. Plant Anatomy1h 3m
34. Vascular Plant Transport1h 2m
- Water Potential
  1h 2m
35. Soil37m
- Soil and Nutrients
  20m
- Nitrogen Fixation
  16m
36. Plant Reproduction47m
- Flowers
  33m
- Seeds
  14m
37. Plant Sensation and Response1h 9m
38. Animal Form and Function1h 19m
39. Digestive System1h 10m
- Digestion
  1h 3m
- Blood Sugar Homeostasis
  7m
40. Circulatory System1h 49m
41. Immune System1h 12m
42. Osmoregulation and Excretion50m
- Osmoregulation and Excretion
  50m
43. Endocrine System1h 4m
- Endocrine System
  1h 4m
44. Animal Reproduction1h 2m
- Animal Reproduction
  1h 2m
45. Nervous System1h 55m
- Neurons and Action Potentials
  1h 8m
- Central and Peripheral Nervous System
  46m
46. Sensory Systems46m
- Sensory System
  46m
47. Muscle Systems23m
- Musculoskeletal System
  23m
48. Ecology3h 11m
49. Animal Behavior28m
- Animal Behavior
  28m
50. Population Ecology3h 41m
51. Community Ecology2h 46m
52. Ecosystems2h 36m
53. Conservation Biology24m
- Conservation Biology
  24m

11. Cell Division

Cell Cycle Regulation

General Biology

11. Cell Division

Cell Cycle Regulation

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Multiple Choice

Which protein complex is primarily responsible for regulating the transition from the G1 phase to the S phase in the eukaryotic cell cycle?

p53-MDM2 complex

Cyclin E/CDK2

Cyclin B/CDK1

Cyclin D/CDK4

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Verified step by step guidance

Understand the eukaryotic cell cycle: The cell cycle consists of four main phases: G1, S, G2, and M. The G1 phase is the first gap phase where the cell grows and prepares for DNA replication, which occurs in the S phase.

Learn about cyclins and CDKs: Cyclins are regulatory proteins that bind to cyclin-dependent kinases (CDKs) to activate them. These complexes play a critical role in controlling the progression of the cell cycle by phosphorylating target proteins.

Focus on the G1 to S phase transition: The transition from G1 to S phase is tightly regulated to ensure the cell is ready for DNA replication. Cyclin D/CDK4 is the primary complex responsible for this transition by phosphorylating the retinoblastoma protein (Rb), which releases E2F transcription factors to initiate S phase gene expression.

Differentiate between the listed complexes: Cyclin E/CDK2 is involved later in the G1 phase and helps finalize the transition to S phase. Cyclin B/CDK1 is associated with the G2 to M phase transition. The p53-MDM2 complex is involved in cell cycle arrest and apoptosis, not the G1 to S phase transition.

Conclude with the correct complex: Cyclin D/CDK4 is the key protein complex that regulates the transition from the G1 phase to the S phase by phosphorylating Rb and promoting the activation of genes required for DNA replication.