Mismatch repair operates during transcription, while nucleotide excision repair functions during replication.
C
Mismatch repair corrects base-pairing errors, while nucleotide excision repair removes bulky DNA lesions.
D
Mismatch repair is involved in repairing double-strand breaks, while nucleotide excision repair fixes single-strand breaks.
Verified step by step guidance
1
Understand the context of DNA repair mechanisms: DNA repair is crucial for maintaining the integrity of genetic information. Different repair mechanisms address specific types of DNA damage.
Mismatch repair (MMR) is a system that corrects errors that occur during DNA replication. These errors typically involve base-pairing mismatches, where incorrect nucleotides are paired together.
Nucleotide excision repair (NER) is a mechanism that removes bulky DNA lesions, such as thymine dimers caused by UV radiation. These lesions distort the DNA helix and need to be excised to restore normal DNA structure.
Identify the key difference: Mismatch repair focuses on correcting base-pairing errors, ensuring that the DNA sequence is accurately replicated. Nucleotide excision repair targets structural distortions in the DNA, removing damaged sections and allowing for proper DNA function.
Consider the implications: Each repair mechanism is specialized for different types of DNA damage, highlighting the complexity and efficiency of cellular repair processes in maintaining genetic stability.