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Multiple Choice
Which of the following genetic diseases affects DNA repair systems in humans?
A
Huntington's disease
B
Xeroderma pigmentosum
C
Sickle cell anemia
D
Cystic fibrosis
Verified step by step guidance
1
Understand the role of DNA repair systems: DNA repair systems are crucial for correcting errors that occur during DNA replication or due to environmental damage. These systems help maintain the integrity of the genetic material.
Identify the nature of each disease: Research the underlying cause of each disease listed. Huntington's disease is caused by a genetic mutation leading to abnormal protein production. Sickle cell anemia is due to a mutation in the hemoglobin gene. Cystic fibrosis is caused by mutations in the CFTR gene affecting ion transport.
Focus on Xeroderma pigmentosum: This condition is directly related to defects in the DNA repair system. Specifically, it involves a deficiency in nucleotide excision repair, a mechanism that repairs UV-induced DNA damage.
Compare the diseases: Note that Xeroderma pigmentosum is unique among the options because it directly involves a malfunction in the DNA repair process, unlike the other diseases which are caused by specific gene mutations affecting protein function.
Conclude that Xeroderma pigmentosum is the disease affecting DNA repair systems, as it is characterized by an inability to repair DNA damage caused by ultraviolet light, leading to increased skin cancer risk.