Multiple Choice
Which of the following is an example of a frameshift mutation?
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15. Gene Expression
Mutations
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Sickle cell disease is caused by a missense mutation that affects which of the following proteins?
A
Insulin
B
Hemoglobin
C
Keratin
D
Collagen
Verified step by step guidance1
Understand that sickle cell disease is a genetic disorder caused by a mutation in a specific protein.
Identify that the mutation involved in sickle cell disease is a missense mutation, which means a single nucleotide change results in a different amino acid in the protein sequence.
Recognize that hemoglobin is the protein affected by this mutation. Hemoglobin is responsible for carrying oxygen in red blood cells.
Recall that the specific mutation in sickle cell disease occurs in the beta-globin chain of hemoglobin, where the amino acid glutamic acid is replaced by valine.
Conclude that the missense mutation in hemoglobin leads to the characteristic sickle shape of red blood cells, causing the symptoms of sickle cell disease.
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