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Multiple Choice
Which of the following is a molecular effect of growth hormone on target cells?
A
Direct inhibition of DNA replication
B
Suppression of glucose uptake in all tissues
C
Activation of gene transcription leading to increased protein synthesis
D
Degradation of cell surface receptors
Verified step by step guidance
1
Understand the role of growth hormone (GH): Growth hormone is a peptide hormone that primarily stimulates growth, cell reproduction, and regeneration in the body. It exerts its effects by binding to specific receptors on target cells.
Recognize the molecular mechanism of GH: Growth hormone binds to its receptor on the cell surface, which activates intracellular signaling pathways, such as the JAK-STAT pathway. This leads to changes in gene expression.
Focus on gene transcription: The activation of the JAK-STAT pathway by GH results in the transcription of specific genes. These genes are responsible for producing proteins that promote growth and metabolism, such as insulin-like growth factor 1 (IGF-1).
Eliminate incorrect options: Direct inhibition of DNA replication is not a known effect of GH. Suppression of glucose uptake in all tissues is not accurate, as GH can have varying effects on glucose metabolism depending on the tissue. Degradation of cell surface receptors is not a primary molecular effect of GH.
Conclude the correct molecular effect: The activation of gene transcription leading to increased protein synthesis is the correct molecular effect of growth hormone on target cells, as it aligns with its role in promoting growth and metabolism.