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Multiple Choice
Which of the following statements about transmembrane domains is true?
A
Transmembrane domains are always composed of beta sheets.
B
Transmembrane domains are only found in the outer leaflet of the lipid bilayer.
C
Transmembrane domains are typically composed of hydrophobic amino acids.
D
Transmembrane domains are exclusively found in peripheral membrane proteins.
Verified step by step guidance
1
Understand the structure of transmembrane domains: Transmembrane domains are regions of a protein that span the lipid bilayer of cell membranes. They are typically composed of hydrophobic amino acids, which allow them to interact with the hydrophobic core of the lipid bilayer.
Evaluate the statement about beta sheets: Transmembrane domains are not always composed of beta sheets. While some transmembrane proteins may have beta-barrel structures, many transmembrane domains are composed of alpha helices.
Consider the location of transmembrane domains: Transmembrane domains are not restricted to the outer leaflet of the lipid bilayer. They span the entire bilayer, interacting with both the inner and outer leaflets.
Assess the statement about peripheral membrane proteins: Transmembrane domains are not found in peripheral membrane proteins. Peripheral proteins are associated with the membrane surface and do not span the lipid bilayer.
Identify the correct statement: The statement that transmembrane domains are typically composed of hydrophobic amino acids is true. This hydrophobic nature allows them to integrate into the lipid bilayer effectively.