Table of contents

1. Matter and Measurements4h 31m
2. Atoms and the Periodic Table5h 23m
3. Ionic Compounds2h 18m
4. Molecular Compounds2h 18m
5. Classification & Balancing of Chemical Reactions3h 17m
6. Chemical Reactions & Quantities2h 27m
7. Energy, Rate and Equilibrium3h 46m
8. Gases, Liquids and Solids3h 25m
9. Solutions4h 10m
10. Acids and Bases3h 29m
11. Nuclear Chemistry56m
BONUS: Lab Techniques and Procedures1h 38m
BONUS: Mathematical Operations and Functions47m
12. Introduction to Organic Chemistry1h 34m
13. Alkenes, Alkynes, and Aromatic Compounds2h 12m
14. Compounds with Oxygen or Sulfur1h 6m
15. Aldehydes and Ketones1h 1m
16. Carboxylic Acids and Their Derivatives1h 11m
17. Amines39m
18. Amino Acids and Proteins1h 51m
19. Enzymes1h 37m
20. Carbohydrates1h 41m
21. The Generation of Biochemical Energy2h 8m
22. Carbohydrate Metabolism2h 22m
23. Lipids2h 26m
24. Lipid Metabolism1h 45m
25. Protein and Amino Acid Metabolism1h 37m
26. Nucleic Acids and Protein Synthesis2h 54m

21. The Generation of Biochemical Energy

The Citric Acid Cycle

GOB Chemistry

21. The Generation of Biochemical Energy

The Citric Acid Cycle

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Multiple Choice

Which enzyme oxidizes α-ketoglutarate in step 4 of the citric acid cycle?

isocitrate dehydrogenase

α-ketoglutarate oxidase

succinyl CoA synthase

α-ketoglutarate dehydrogenase

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Verified step by step guidance

Understand the context: The citric acid cycle, also known as the Krebs cycle, is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins into carbon dioxide and chemical energy.

Identify the role of enzymes: Enzymes are biological catalysts that speed up the rate of chemical reactions without being consumed in the process. In the citric acid cycle, each step is facilitated by a specific enzyme.

Focus on step 4 of the citric acid cycle: In this step, α-ketoglutarate is converted into succinyl-CoA. This conversion involves the oxidation of α-ketoglutarate.

Determine the enzyme responsible for this oxidation: The enzyme that catalyzes the oxidation of α-ketoglutarate to succinyl-CoA is α-ketoglutarate dehydrogenase. It facilitates the removal of electrons from α-ketoglutarate, which is a key part of the oxidation process.

Clarify the options: Among the given options, α-ketoglutarate dehydrogenase is the correct enzyme responsible for the oxidation of α-ketoglutarate in step 4 of the citric acid cycle.