Textbook Question
Which of the following molecules will produce the most ATP per mole?
e. 𝛼-ketoglutarate or fumarate in one turn of the citric acid cycle
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21. The Generation of Biochemical Energy
The Citric Acid Cycle
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Which one of the following enzymes catalyzes the addition of water to the C=C bond in fumarate?
A
Fumarate reductase
B
Malate synthase
C
Fumarase (Fumarate hydratase)
D
Malate dehydrogenase
Verified step by step guidance1
Identify the reaction type: The problem involves the addition of water to a C=C bond, which is a hydration reaction.
Understand the role of enzymes: Enzymes that catalyze hydration reactions typically add water across double bonds.
Review the function of each enzyme: Fumarate reductase is involved in the reduction of fumarate, not hydration. Malate synthase is involved in the synthesis of malate, not directly adding water to fumarate. Malate dehydrogenase catalyzes the oxidation of malate to oxaloacetate, not hydration.
Focus on fumarase: Fumarase, also known as fumarate hydratase, specifically catalyzes the hydration of fumarate to malate by adding water across the C=C bond.
Conclude with the correct enzyme: Based on the functions, fumarase is the enzyme that catalyzes the addition of water to the C=C bond in fumarate, converting it to malate.
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