Table of contents

1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart3h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

3. Energy & Cell Processes

Cell Cycle Regulation

Anatomy & Physiology

3. Energy & Cell Processes

Cell Cycle Regulation

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Multiple Choice

How is the activity of Maturation Promoting Factor (MPF) controlled in the cell cycle?

By the binding of calcium ions

By the synthesis of new ribosomes

By the phosphorylation and dephosphorylation of its subunits

By the degradation of DNA

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Verified step by step guidance

Understand that Maturation Promoting Factor (MPF) is a complex of cyclin and cyclin-dependent kinase (CDK) that plays a crucial role in regulating the cell cycle, particularly the transition from G2 phase to M phase.

Recognize that the activity of MPF is primarily controlled through the phosphorylation and dephosphorylation of its subunits. This means that the addition or removal of phosphate groups to the CDK subunit can activate or deactivate the MPF complex.

Phosphorylation is the process of adding a phosphate group to a molecule, often mediated by enzymes known as kinases. In the case of MPF, specific kinases add phosphate groups to the CDK, which can either activate or inhibit its activity depending on the site of phosphorylation.

Dephosphorylation is the removal of a phosphate group, typically carried out by enzymes called phosphatases. For MPF, dephosphorylation of certain sites on the CDK subunit is necessary for its activation, allowing the cell to progress into mitosis.

The regulation of MPF through phosphorylation and dephosphorylation ensures that the cell cycle progresses in a controlled manner, preventing premature or inappropriate entry into mitosis, which is crucial for maintaining genomic stability.