BackThe following is a segment of the template strand of human BRCA1 gene:
TGG AAT TAT CTG CTC TTC GCG
c. If there is a point mutation in the fourth nucleotide triplet and A replaces G, what is the change, if any, in the amino acid sequence?
Answer the following questions for the given section of DNA:
c. Write the three-letter symbols for the amino acids that would go into the peptide from the mRNA you wrote in part b.
Suppose a mutation occurs in the DNA section in problem 17.89, and the first base in the parent chain, adenine, is replaced by guanine.
c. Write the three-letter symbols for the amino acids that would go into the peptide from the mRNA you wrote in part b.
Suppose a mutation occurs in the DNA section in problem 17.89, and the first base in the parent chain, adenine, is replaced by guanine.
a. What type of mutation has occurred?
Match each of the following processes (1 to 5) with one of the items (a to e):
5. reverse transcription
a. amino acids are linked together
b. RNA template is used to synthesize DNA
c. helicase unwinds DNA
d. genetic information is transferred from DNA
e. sticky ends join new DNA segment
Suppose a mutation occurs in the DNA section in problem 17.89, and the first base in the parent chain, adenine, is replaced by guanine.
d. What effect, if any, might this mutation have on the structure and/or function of the resulting protein?
Consider the following portion of mRNA produced by the normal order of DNA nucleotides:
5'CUU|AAA|CGA|GUU3'
c. Write the amino acid sequence if a mutation changes CGA to AGA. Is this likely to affect protein function?
Consider the following portion of mRNA produced by the normal order of DNA nucleotides:
5'CUU|AAA|CGA|GUU3'
e. What happens to the protein sequence if an A is added to the beginning of the chain and the sequence changes to 5'ACU|UAA|ACG|AGU3'?
Consider the following portion of mRNA produced by the normal order of DNA nucleotides:
5'ACA|UCA|CGG|GUA3'
c. Write the amino acid sequence if a mutation changes CGG to GGG. Is this likely to affect protein function?
Consider the following portion of mRNA produced by the normal order of DNA nucleotides:
5'ACA|UCA|CGG|GUA3'
f. What happens to the protein sequence if the A is removed from the beginning of the chain and the sequence changes to 5'CAU|CAC|GGG3'?
Provide the three-letter amino acid sequence expected from each of the following mRNA segments:
b. 5'UUU|CCC|UUU|CCC3'
Consider the following portion of mRNA produced by the normal order of DNA nucleotides:
5'CUU|AAA|CGA|GUU3'
a. Write the amino acid sequence that would be produced from this mRNA.
What is the one-letter amino acid sequence formed from the following mRNA that codes for a pentapeptide that is an endorphin called Met-enkephalin?
5'AUG|UAC|GGU|GGA|UUU|AUG|UAA3'
A base substitution changes a codon for an enzyme from GCC to GCA. Why is there no change in the amino acid order in the protein?
A protein contains 35 amino acids. How many nucleotides would be found in the mRNA code for this protein?